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Who wins?

Ryze vs Mel

Mel wins 53% to 47%. 103 more put them in the same row. From League of Legends: Mid Laners Tier List. Pick a side.

tony.t8016 on Ryze: ryze got his early game nerfed in 26.12 (base health 645 to 620, AD 58 to 55) and by 26.19 he was D at 47.0%
throwaway67991 on Mel: mel mid has been D tier in every snapshot this year, 47.7% win rate on 26.20

League of Legends: Mid Laners Tier List: the full ranking

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